Hyperpolarized 13C metabolic imaging is a powerful technique with proven safety and efficacy for human studies. The goal of this project was to investigate pyruvate metabolism in patients with prostate and breast cancer metastases with both echo-planar spectroscopic imaging (EPSI) and the echo-planar imaging (EPI) acquisitions in the same exam. The results revealed similarly valuable information of up-regulated LDH-catalyzed conversion of pyruvate to lactate with some advantages and differences between the two acquisition methods.
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