Abstract #0127

Two Dimensional COSY on Biopsy Distinguishes Indolent From Aggressive Kidney Masses

Aaron Urquhart¹, Sharon Del Vecchio², Lutz Krause³, Robert Ellis², Keng Lim Ng⁴, Hema Samaratunga⁵, Sonja Gustafson⁶, Graham Galloway^1,3, Glenda Gobe², Peter Malycha¹, Simon Wood⁴, and Carolyn Mountford¹

¹Translational Research Institute, Brisbane, Australia, ²Faculty of Medicine, The University of Queensland, Brisbane, Australia, ³The University of Queensland, Brisbane, Australia, ⁴Department of Urology, Princess Alexandra Hospital, Brisbane, Australia, ⁵Aquesta Uropathology, Brisbane, Australia, ⁶Department of Radiology, Princess Alexandra Hospital, Brisbane, Australia

Kidney tumour metabolism may have chemical signatures that distinguish indolent from aggressive small renal masses (SRM). Indolent or benign SRM could be managed conservatively. Here we have used two dimensional (2D) COrrelation SpectroscopY (COSY) on nephrectomy samples to assign and measure metabolite and lipid resonances. High level bioinformatics analysis was then applied. We report metabolic chemical signatures that can be used to distinguish histologically-diagnosed kidney tumour subtypes.

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