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Abstract #0403

MR/ fluorescence dual-modality image-guided multifunctional albumin nanoassembies for sonodynamic therapy of glioma

Qian Wan1,2, Chao Zou1, Mengjie Chen3, Zonghai Sheng1, Jun Zhou3, Yanwen Zhu3, Hairong Zheng1, and Xin Liu1

1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2University of Chinese Academy of Sciences, Beijing, China, 3The First College of Clinical Medical Sciences´╝îChina Three Gorges Unversity, Yichang, China

Sonodynamic therapy (SDT) is a non-invasive and effective therapeutic modality for solid cancerous tumors. In this study, to improve the effectiveness of SDT, we fabricated a high-performance multifunctional albumin nanoassembies (HSA-Ce6-Mn NCs) having higher cell uptake efficiency and the tumor accumulation. It also exhibited an excellent ability of MR/ fluorescence (FL) dual-modality imaging so that glioma margin and HSA-Ce6-Mn NCs metabolism could be clearly visualized. The SDT has been demonstrated for suppressing the tumor growth in-vivo under a MRI-guided FUS system and it is highly expected to have a great potential in clinical translation.

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