This study evaluates the potential association of coronary plaque burden with traditional atherosclerosis risk factors and coronary wall thickness (VWT) measured with time-resolved phase-sensitive dual-inversion black-blood TRAPD-MRI. The study demonstrates that there is substantial coronary plaque burden in asymptomatic subjects at low and intermediate Framingham score. In addition, there was evidence of a gender-dimorphic association between the predictors and plaque burden. In women, coronary wall thickness was the strongest and common significant predictor for all plaque burden scores and the presence of calcification. Meanwhile in men, age was the strongest and common predictor of all plaque burden scores and the presence of calcification. This suggests that atherogenesis in women may differ from men and that VWT could supplement traditional risk scores for CAD risk stratification in women. This is in line with the previous studies that demonstrated the impaired utility of these CAD risk score models for women compared to men.
This abstract and the presentation materials are available to members only; a login is required.