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Abstract #0847

Connectome of the Extremely Preterm Brain at Adolescence and Measures of Cognitive Functioning: Early Experience with White Matter Fibrography (WMF)

Hernan Jara1, Osamu Sakai1, Stephan W Anderson1, Timothy Heeren1, Karl CK Kuban1, and Thomas M O'Shea2

1Boston University, Boston, MA, United States, 2University of North Carolina Children’s Hospital, Chapel Hill, NC, United States

Purpose: To analyze the fiber bundle architecture via white matter connectomes of extremely preterm (EP) born adolescents generated by Synthetic-MRI based white matter fibrography, and to study associations with summary measures of intelligence quotient (IQ) and executive function (EF). Methods: Eleven EP adolescents were scanned the tri-turbo spin echo pulse sequence, which is the concatenation of dual-echo TSE and single-echo TSE pulse sequences, both acquired with same geometry and scanner settings. Results: Connectome were successfully created for all subjects. Conclusion: White matter fibrography is a direct and reliable method for generating whole-brain white matter connectomes in adolescents born EP, and appears to have clinical relevance.

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