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Abstract #0848

Long term Brain Functional Connectivity changes after Neonatal Arterial Ischemic Stroke (NAIS): A resting state fMRI study

Lucie Hertz-Pannier1, Dhaif Bekha1, Victor Delattre1, David Germanaud1, Laure Drutel2, Edouard Duchesnay3, Marion Noulhiane1, Cyrille Renaud4, Manoelle Kossorotoff5, Mickael Dinomais2, Stephane Chabrier4, and Sylvie N Guyen The Tich6

1Institute Joliot/DRF/CEA, U1129/UNIACT, Neurospin, CEA-Saclay, Gif sur Yvette, France, 2Département de SSR pédiatrique, CHU Angers, Angers, France, 3Institute Joliot/DRF/CEA, UNATI, Neurospin, CEA-Saclay, Gif sur Yvette, France, 4Departement de Rééducation Fonctionnelle, CHU Saint Etienne, Saint Etienne, France, 5University Hospital Necker-Enfants Malades, Paris, France, 6CHU Lille, Lille, France

Resting state fMRI enables the study of plastic inter- and intra- hemispheric connectivity changes after early brain lesions. We studied 38 7yo children having suffered an arterial ischemic stroke in the neonatal period (NAIS) and 29 age-matched controls, with rs-fMRI, and language fMRI. Preprocessing took into account various sources of spurious signals (motion, lesion, interdependency of correlation measures, etc…). Tangent metric appeared the most accurate to classify groups of subjects and highlighted mostly a reduced inter-hemispheric connectivity in the auditory, language, and attentional networks, especially in patients with atypical clinical or fMRI language profiles, but with little evidence for intra-hemispheric changes.

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