Abstract #0968

Measurements of human brown adipose tissue temperature during cold exposure by hyperpolarized xenon MR thermometry

Rosa Tamara Branca^1,2, Le Zhang^2,3, Alex Burant^1,2, Michael Antonacci^1,2, Andrew McCallister^1,2, and Laurence Katz⁴

¹Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁴Dept of Emergency Medicine, Exercise and Sports Science, University of North Carolina school of medicine, Chapel Hill, NC, United States

While temperature measurement represents the most direct way to measure BAT thermogenic function, temperature measurements by proton-based MR methods are confounded by magnetic susceptibility effects, which cannot be corrected for at the microscopic level. Here we report our first measurements of absolute BAT temperature in adult humans during cold exposure by hyperpolarized xenon gas MRI. These measurements represent the most direct way to measure thermogenic function in BAT.

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