Abstract #0978

CO2-challenge measured with dual echo arterial spin labeling as a whole brain biomarker to assess the effect of amyloid deposition in HCHWA-D on the cerebrovascular reactivity.

Sophie Schmid^1,2, Jasper Verbree¹, Merlijn C.E. van der Plas^1,2, Ellis S. van Etten³, Ingeborg Rasing³, Pauline H. Croll⁴, Madeline Redelijkheid^2,4, Gerda Labadie⁴, Gisela M. Terwindt³, Marieke J.H. Wermer³, Mark A. van Buchem⁴, and Matthias J.P. van Osch^1,2

¹C.J. Gorter Center, Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden Institute of Brain and Cognition (LIBC), Leiden, Netherlands, ³Neurology, Leiden University Medical Center, Leiden, Netherlands, ⁴Radiology, Leiden University Medical Center, Leiden, Netherlands

In this study a CO₂-challenge was applied to test the effect of amyloid deposition in HCHWA-D, a hereditary form of cerebral amyloid angiopathy (CAA), on the cerebrovascular reactivity (CVR). With dual echo arterial spin labeling, providing cerebral blood flow (CBF) and BOLD images, the CVR was measured in grey and white matter and the CO₂-challenge was evaluated as a whole brain biomarker. The effect of the CO₂-challenge was best measured with CBF in the grey matter. Future research should prove whether it is sensitive enough to detect treatment induced changes in (pre-)symptomatic CAA patients.

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