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Abstract #1055

Transient intrinsic torsional shear wave propagation demonstrates a difference in Left Ventricular Myocardial stiffness between volunteers and patients with HFpEF

Jessica Webb1,2, Jurgen Runge1, Omar Darwish1, Alessandro Polcaro1,3, Torben Schneider4, Gerald Carr-White1,2, Jordi Martorell3, David Nordsletten1, Reza Razavi1,2, and Ralph Sinkus1

1King's College London, London, United Kingdom, 2Guys and St Thomas' NHS Trust, London, United Kingdom, 3Universitat Ramon Llull, Barcelona, Spain, 4Philips Healthcare, Guildford, United Kingdom

Heart Failure with preserved Ejection Fraction is common, associated with high morbidity and mortality, and is challenging to diagnose. We have developed a novel patient friendly non-invasive technique to quantify myocardial stiffness using transient MR Elastography. Aortic valve closure results in the propagation of a transient shear wave through the myocardium. Torsional wave propagation can be visualised using a 1D pencil beam navigator positioned longitudinally along the myocardial septum, using four breath holds each 15 seconds. Providing a temporal resolution of 0.3ms, we observe increased myocardial stiffness in HFpEF patients compared to healthy volunteers (torsional speed 5.5 ± 1.1 m/s in volunteers and 10.0 ± 0.7 m/s in Patients; stiffness 36 ± 12.0 kPa and 108 ± 15.2 kPa, respectively) .

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