Meeting Banner
Abstract #1092

Probing microstructure with different tomographic methods: Comparing dMRI and X-ray scattering-derived parameters in mouse and human brains

Marios Georgiadis1,2, Dmitry S. Novikov1, Manuel Guizar-Sicairos3, Marianne Liebi3,4, Vivianne Lutz-Bueno3, Benjamin Ades-Aron1, Timothy M. Shepherd1, Aileen Schroeter2, Markus Rudin2, and Els Fieremans1

1NYU Langone Medical Center, New York, NY, United States, 2ETH Zurich, Zurich, Switzerland, 3Paul Scherrer Institute, Villigen, Switzerland, 4Chalmers University of Technology, Gothenburg, Sweden

Despite MRI’s coarse resolution, diffusion MRI (dMRI) enables probing cellular microstructure. Advanced dMRI acquisition and biophysical modeling can provide microstructural metrics related to disease processes, and spherical harmonics (SH)-based orientation distribution function (ODF). Yet, these still need structural validation, and a gold standard for quantifying microstructure, particularly fiber dispersion, is missing. X-ray scattering directly probes tissue microstructure, exploiting the ~17nm myelin repeat distance, and can also represent ODF in a SH basis. Here, we show good correspondence between SH coefficients from dMRI and X-ray scattering on a mouse brain, with analysis on human samples and histological validation to follow.

This abstract and the presentation materials are available to members only; a login is required.

Join Here