The quantification of glycine (Gly) with in vivo MRS is challenging due to the strong spectral overlap with myo-inositol (mI) so that only the concentration sum mI+Gly can be accurately measured with standard MRS methods at clinical field strengths. In this work, the distinction and quantification of mI and Gly is demonstrated with S-PRESS difference editing, which enables unequivocal detection of the strongly coupled mI resonances through suppression of the overlapping uncoupled Gly resonance.
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