Metabolic imaging of glioblastoma using hyperpolarized 13C-MRI - glycolytic metabolism in cancer stem cell-like cells.
Tatsuya Kawai1, Jeffery Brender2, Kevin Camphausen1, and Murali C Krishna2
1Radiation Oncology Branch, National Cancer Institute, NIH, Bethesda, MD, United States, 2Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD, United States
Dynamic nuclear polarization-MRI along with hyperpolarized [1-13C] pyruvate was conducted to evaluate the difference in glycolytic profile between a glioblastoma cell line and cancer stem-like cells using the orthotopic xenograft mouse model.
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