At low magnetic fields, T1 variation within cartilage is a robust parameter that is employed to quantify the layered structure in the tissue and is sensitive to factors such as enzymatic degradation, external load, and diseases such as osteoarthritis. Variable-field relaxometry provides access to the content and local order of glycosaminoglycans and collagen via proton-nitrogen quadrupolar dips. In this study on 20 human cartilage samples, load-dependent low-field and variable-field techniques were combined for the first time to correlate NMR parameters with the severity of osteoarthritis.
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