Characterization of endometrioid adenocarcinoma microcirculation using distributed parameter model in DCE MRI

Objective: To clarify the features of vascular proliferation and permeability in endometrioid adenocarcinoma. Methods: The DCE-MRI was applied to 55 women who confirmed as endometrioid adenocarcinoma with postoperative pathology. The receiver operating characteristic (ROC) analysis was employed using parameters derived with the DP model to differentiate tumor and normal myometrium and assess the diagnostic efficiency of these parameters. Results: E and PS in tumor was lower. F in tumor was faster. Vp and Ve in tumor were lower. Areas under ROC curve (AUCs) for E and PS attained values of 0.906 and 0.844. AUCs for F attained value of 0.548. Vp and Ve in tumor with AUC values of 0.796 and 0.871. Conclusion: The permeability of vascular wall was significantly lower in endometrioid adenocarcinoma, and the vascularity was moderately lower, suggestive of very different cell growth environment in endometrioid adenocarcinoma in comparison with most solid tumours.