Abstract #2012

MR Spectroscopy in a Transgenic Rat Model of Alzheimer’s Disease

Wendy Oakden¹, Christina Beckett¹, Bojana Stephanovic^1,2, Greg J Stanisz^1,2,3, and JoAnne McLaurin^4,5

¹Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, ²Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Lublin, Poland, ⁴Biological Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, ⁵Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

The transgenic rat model of Alzheimer’s Disease (AD), TgF344-AD rats, manifests a more complete spectrum of age-dependent AD pathologies in conjunction with cognitive disturbance. Importantly, TgF344-AD rats exhibit amyloid and tau pathology as well as frank neuronal loss with aging. This study investigates brain metabolic changes, using magnetic resonance spectroscopy, in older TgF344-AD animals relative to younger and to non-transgenic littermate rats. Our data shows a statistically significant decrease in phosphocreatine, glutamate, and taurine, and a trend towards decreased NAA (p=0.053) in comparison to the combined younger and non-transgenic littermate rats.

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