The epidemiological data suggested more prevalence of AD in females than males. To understand the severity of AD in females, we have performed behavioral and neurometabolic analysis in female and male 3xTg-AD mice. Though, the learning and memory are impaired in both male and female AD mice, there is no neurometabolic impairment in female 3xTg-AD mice. In contrary, neurometabolism was severely compromised in male AD mice. The data from the current study suggest more severe AD in males as compared to females till their reproductive age.