The developing brain has a powerful
ability to modify its own structure and function for recovery from injury in
efforts to compensate for loss of function1,2. In critical period, developing
brain has maximal neuronal synaptic connections so it is most amenable to
changes in response to external stimulus such as physical exercise3.
However, after critical period, neuronal synaptic connections are reduced, and
maintained at the reduced state3. Here, we demonstrate enhanced
neuroplasticity with physical exercise performed beyond critical period for
rats that are injured during critical period. We obtained the BOLD-fMRI response
and the interneuron activity with LFP electrophysiological recording.