Brain tumor dynamic susceptibility contrast (DSC) MRI is adversely impacted by contrast agent leakage that results in confounding T1 and T2* effects. While multi-echo acquisitions remove T1 leakage effects, there is no consensus on the optimal set of acquisition parameters. Using a validated DSC-MRI digital reference object (DRO), we assessed the influence of preload dosing, pulse sequence parameters (number of echoes, TEs, TR, FA), and leakage correction method on cerebral blood volume (CBV) accuracy. This computational approach permits the systematic evaluation of a wide range of acquisition strategies to determine the optimal multi-echo DSC-MRI perfusion protocol.
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