This work compares three kinetic models for evaluation of DCE-MRI in high-grade gliomas: the Tofts-Kermode (TK) model, the extended Tofts model (ETM) and the two-compartment exchange (TCE) model. 25 patients underwent a combined 238 examinations, and kinetic analysis was performed using the three models. In tumor regions where the data was better fitted using TK or TCE, median Ktrans estimates obtained from this model was compared to that from using ETM. It was found that in tumor regions in which TCE provides the best fit, median Ktrans was significantly underestimated when applying ETM.
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