Abstract #2230

Multiple Interleaved Mode Saturation (MIMOSA) for B1+ inhomogeneity mitigation in chemical exchange saturation transfer.

Andrzej Liebert¹, Moritz Zaiss², Rene Gumbrecht³, Benjamin Schmitt⁴, Peter Linz¹, Frederik B. Laun¹, Michael Uder¹, and Armin M. Nagel¹

¹Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ²Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ³Siemens Healthcare GmbH, Erlangen, Germany, ⁴Siemens Healthcare Pty Ltd, Sydney, Australia

Due to high sensitivity to B₁⁺-inhomogeneities, Chemical Exchange Saturation Transfer MRI requires a correction or mitigation of the B₁⁺-inhomogeneity at ultra-high magnetic field strengths (B₀≥ 7 Tesla). A novel approach for mitigation of B₁⁺-inhomogeneity effects that affects the saturation process is presented. The method employs two interleaved excitation modes during the saturation pulse train. Simulations show a decrease of the relative difference of the MTRRex metric caused by B₁⁺ inhomogeneity. This “Multiple Interleaved Mode Saturation” scheme leads to improved homogeneity in both, phantom and in vivo measurements at 7 Tesla.

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