Mutations in gene MYBPC3, encoding cardiac myosin-binding protein C, cause hypertrophic cardiomyopathy (HCM), which is characterized by left ventricular hypertrophy (LVH), diastolic dysfunction, increased interstitial fibrosis, and may lead to sudden cardiac death and heart failure. In spite of the advances in translational medicine, we know very little about HCM. The HCM progression is complex and shows heterogeneous phenotypes. The missing linkage of in vivo imaging and pathology has hindered the investigation of detail mechanisms of HCM. We therefore investigated Mybpc3-targeted mouse models using CMR markers for understanding HCM pathophysiology and to get closer to complete pictures of HCM progression.