Type 2 diabetes doubles the risk of myocardial infarction in women. New treatments need to be found to reduce cardiovascular mortality. Consequently, we investigated the effect of Resveratrol (RSV) on the tolerance to ischemia-reperfusion (IR) injury of type 2 diabetic female Goto-Kakizaki (GK) rat heart. We used a multiparametric approach allowing simultaneous measurement of cardiac function, energy metabolism by 31P MRS and endothelial function. Oral RSV treatment improved myocardial performance, coronary flow and energy metabolism during reperfusion in GK rats. Consequently, RSV might be an interesting therapeutic approach to improve survival to myocardial IR injury of type 2 diabetic women.