Abstract #3034

Benzene-Appended Cucurbit[6]uril as a Potential Biosensor Scaffold for Hyperpolarized 129Xe MRI Molecular Contrast Agents

Braedan R. J. Prete¹, Dave Robinson², Ashvin Fernando², Yurii Shepelytskyi¹, Alanna Wade¹, Francis T. Hane^1,3, Brenton DeBoef², and Mitchell S. Albert^1,3,4

¹Chemistry, Lakehead University, Thunder Bay, ON, Canada, ²Chemistry, University of Rhode Island, Kingston, RI, United States, ³Thunder Bay Regional Health Research Institute, Thunder Bay, ON, Canada, ⁴Biology, Northern Ontario School of Medicine, Thunder Bay, ON, Canada

We have recently advanced the field of hyperpolarized (HP) ¹²⁹Xe magnetic resonance imaging (MRI) with the in vivo detection of cucurbit[6]uril (CB6), a highly sensitive MR contrast agent. CB6 is biochemically inactive, which makes its natural bio-distribution non-specific; thus, it cannot be precisely localized within a living mammalian body using HP ¹²⁹Xe MRI. We have previously identified cyclodextrin-based pseudorotaxanes as conjugatable scaffolds for xenon biosensors; in this work, we introduce a second class of conjugatable scaffolds, with the hyperCEST detection of benzene-appended CB6, a potential precursor to a wide variety of targeted molecular imaging probes.

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