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Abstract #3165

Resting-state fMRI study of brain activation using low-intensity repetitive transcranial magnetic stimulation in rats.

Bhedita J Seewoo1,2,3, Kirk W Feindel3, Sarah J Etherington2, and Jennifer Rodger1,4

1Experimental and Regenerative Neurosciences, School of Biological Sciences, The University of Western Australia, Crawley, Australia, 2School of Veterinary and Life Sciences, Murdoch University, Murdoch, Australia, 3Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, Nedlands, Australia, 4Perron Institute for Neurological and Translational Research, Perth, Australia

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique used to treat many neuropsychiatric conditions. However, the mechanisms underlying its mode of action are still unclear. This is the first rodent study using resting-state fMRI to examine low-intensity (LI) rTMS effects, in an effort to provide a direct means of comparison between rodent and human studies. Our study shows that similar to human rTMS, 10 Hz LI- rTMS alters the resting brain activity of rats directly at the site of stimulation (e.g. cortex) as well as in remote but inter-connected brain regions (e.g. hippocampus).

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