Abstract #3693

Manganese Complex of EDTA-Ethoxybenzyl Conjugate as a New Hepatobiliary MRI Contrast Agent

Md Kamrul Islam¹, Soyeon Kim¹, Hee-Kyung Kim^2,3, Garam Choi¹, Ah Rum Baek¹, Taekwan Lee⁴, DongKyu Kim⁴, Hoe Su Jung⁴, and Yongmin Chang^1,2,5

¹Medical and Biological Engineering, Kyungpook National University, Daegu, Republic of Korea, ²Department of Molecular Medicine & BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University, Daegu, Republic of Korea, ³Institute of Biomedical Engineering Research, Kyungpook National University, Daegu, Republic of Korea, ⁴Laborstory Animal Center, Daegu Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea, ⁵Department of Radiology, Kyungpook National University, Daegu, Republic of Korea

The purpose of the current study is to design and synthesis of novel Mn²⁺ complex as an alternative to well-established Gd³⁺ chelates for use as a liver-targeting MR imaging agent. This new complex exhibits high R₁ relaxivity (2.3 mM⁻¹ s⁻¹) than clinically approved Mn-DPDP® (1.6 mM⁻¹ s⁻¹) at 1.5 T. It is also kinetically much inert than that of Magnevist®. In vivo MRI enhancement pattern compares well with those of liver-specific MRI CAs such as Primovist® and Multihance®. It shows greater tumor detection in a liver tumor model with negligible toxicity in a clinical dose.

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