Meeting Banner
Abstract #3704

Establishing a Dose-Response Relationship for Lithium-Induced Modulation of [1-13C]Pyruvate Metabolism in the Heart

Jonas Steinhauser1, Patrick Wespi1, Grzegorz Kwiatkowski1, and Sebastian Kozerke1

1Institute for Biomedical Engineering, ETH and University Zurich, Z├╝rich, Switzerland

Lithium is the first-line drug used in bipolar disorder, a chronic widespread psychiatric disease. Lithium is a narrow therapeutic index drug and shows cardiac side effects. The present work demonstrates the detectability of lithium induced changes of mitochondrial metabolism in cardiomyocytes using hyperpolarized [1-13C]pyruvate magnetic resonance imaging of the in-vivo rat heart. Metabolic and functional response to lithium was examined for different lithium plasma concentrations.

This abstract and the presentation materials are available to members only; a login is required.

Join Here