Women with Breast Cancer Gene mutations (BRCAm) are recommended to undergo prophylactic bilateral salpingo-oophorectomy prior to natural menopause (PNM-BSO) in order to reduce the risk of ovarian cancer. This surgery is associated with an increased risk of developing Alzheimer's disease (AD). In comparison with healthy women, BRCAm women who had undergone PNM-BSO exhibited decreased gray matter volume across frontal and medial-temporal regions, as measured using the quantitative QRAPMASTER sequence. These regions included many previously linked with AD including, parahippocampal gyrus, cingulate cortex, and inferior temporal gyrus. White matter reductions were only observed in a limited number of superior longitudinal tracts.