The standard of clinical care, Prostate Imaging, Reporting and Diagnosis System (PI-RADS), does not tap into the wealth of quantitative imaging information contained in the multiple sequences of mpMRI, nor does it elucidate intralesional spatial heterogeneity. A habitat risk score (HRS) approach that combines the quantitative information from the diffusion and perfusion mpMRI sequences is developed. HRS was devised in ten subcategories with increasing levels associated with a greater risk of harboring higher Gleason Score's and depicted as a heat map. The automated method is used to define radiotherapy (RT) boost volumes in the background of a randomized Phase II clinical trial.
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