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Abstract #3799

Longitudinal response monitoring in experimental prostate tumors by DCE-MRI after C-12 ion and photon radiotherapy

Alina Leandra Bendinger1, Christian Peter Karger2,3, Charlotte Debus4, Ralf Omar Floca3,5, Jürgen Debus3,6, Jörg Peter1, and Christin Glowa2,3,6

1Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 3Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany, 4Translational Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 5Division of Medical Image Computing, German Cancer Research Center (DKFZ), Heidelberg, Germany, 6Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany

Dynamic contrast-enhanced MRI was used for the longitudinal monitoring of two well characterized experimental prostate tumors (Dunning R3327-AT1 and -HI) after isodose and isoeffective radiotherapy. The effect of carbon (12C)-ion irradition compared to photons on tumor vasculature was characterized by non-compartmental analysis and pharmacokinetic modelling employing the extended Tofts model. Isodose and isoeffective irradiation experiments indicated that the beam modality has a stronger effect on tumor perfusion and permeability than the dose. While changes in perfusion were identified for the highly undifferentiated AT1-tumor, the more differentiated HI-tumor showed only minor changes in perfusion upon irradiation.

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Abstract