Abstract #4002

Mapping longitudinal changes in brain oxygenation in vascular cognitive impairment using 19F-MRI

Ahmed A Khalil^1,2,3, Susanne Mueller^1,4, Marco Foddis¹, Janet Lips¹, Ulrich Dirnagl¹, Sebastian Temme⁵, Ulrich Floegel⁵, and Philipp Boehm-Sturm^1,4

¹Department of Experimental Neurology and Center for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany, ²Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, Germany, ³Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁴Cluster of Excellence NeuroCure and Charité Core Facility 7T Experimental MRIs, Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁵Institute of Molecular Cardiology, Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany

We assessed tissue oxygenation with 19F-MRI using perfluorocarbon emulsions in a mouse model of vascular cognitive impairment. Brain T1 values were measured using a cryogenic 19F/1H coil at multiple timepoints before and after surgery to induce bilateral common carotid artery stenosis and converted to pO₂. T1 values decreased with increasing concentration of inhaled oxygen, and we observed a decrease in tissue pO₂ following surgery which gradually recovered over four weeks. 19F-MRI of perfluorocarbon emulsions can be used for long-term assessment of brain tissue pO₂ in vivo and may be relevant for monitoring endogenous or induced regenerative processes.

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