The accuracy of fMRI-constrained EEG/MEG source imaging may be degraded by potential spatial mismatches between the locations of fMRI activation and electrical source activities. To address this problem, we propose a novel fMRI informed time-variant constraint (FITC) method. Simulations were performed to compare the source estimates produced by L2-minimum norm estimation (MNE), fMRI-weighted minimum norm estimation (fMNE), FITC and depth-weighted FITC (wFITC) algorithms with various spatial mismatch conditions. In conclusion, the proposed FITC method is able to better resolve the spatial mismatch problems encountered in fMRI-constrained EEG/MEG source imaging.
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