As the most commonly used fMRI technique for human brain study, BOLD functional MRI is not detecting neuronal activity directly and the mechanism is not clear. Here we demonstrate, for the first time, to directly explore the relationship between the regional DA neurotransmitter release and the co-localized BOLD signaling in vivo by combing molecular – level dopamine-sensitive MRI technique and BOLD fMRI. Our result demonstrated nonlinear and spatially‐heterogeneity relationships between neurotransmitter activity and the hemodynamic responses in the same region. We expect the result will facilitate a better understanding and explanation of human fMRI results.
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