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Abstract #4875

Elevated NT-proBNP in a Community Cohort is Associated with Myocardial Fibrosis: the Multi-Ethnic Study of Atherosclerosis (MESA)

Chia-Ying Liu1, Susan R Heckbert2, Shenghan Lai3, Bharath Amable-Venkatesh4, Mohammad R Ostovaneh4, Robyn L McClelland5, Joao A.C Lima4, and David A Bluemke6

1Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, United States, 2Department of Epidemiology, University of Washington, Seattle, WA, United States, 3Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, United States, 4Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, United States, 5Department of Biostatistics, University of Washington, Seattle, WA, United States, 6David Bluemke, University of Wisconsin, Madison, WI, United States

We evaluated the relationship between cardiac MRI measures of fibrosis and NT-proBNP levels in 1334 participants in the Multi-Ethnic Study of Atherosclerosis (MESA). Univariate and multivariable regression analyses adjusting for demographics, cardiovascular risk factors, and left ventricular (LV) mass were performed to examine the association of log NT-proBNP with MRI T1 mapping indices. In the fully adjusted model, each one standard deviation increment (0.44pg/mL) of log NT-proBNP was associated with 0.62% increment in ECV (P<0.001), 4.7ms increment in native T1 (P=0.001), and 0.01 increment in partition coefficient (P<0.001). Elevated NT-proBNP is related to subclinical fibrosis in a community-based setting.

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