We developed a new method for myocardial oxygenation using oxygen-inhalation blood-oxygen-level-dependent (BOLD) T2* cardiac magnetic resonance imaging (T2*-CMR). Myocardial oxygenation (ΔR2*, ms-1) was defined as the difference in R2* between under room-air and oxygen inhalation. ΔR2* is increased in patients with hypertrophic cardiomyopathy who had large LGE areas and low strains, suggesting that impairment of myocardial oxygenation associates with myocardial fibrosis and systolic dysfunction. In addition, T2*-CMR with compressed SENSE enables to shorten scan time and less motion artifact. This contributes to make high precision of T2* and R2* maps.