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Abstract #4878

Free-Breathing Myocardial T1-Acquisition with Region-based Analysis is Feasible to Quantify Diffuse Myocardial Fibrosis

Mao-Yuan Marine Su1, Yu-Sen Huang1, Yeun-Chung Chang1, Shun-Chung Yang1, Kui-Yuan Ho2, Lian-Yu Lin3, Cho-Kai Wu3, and Wen-Yih Isaac Tseng1,4

1Dpt of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, 2Dpt of Medical Imaging, Cathay General Hospital, Taipei, Taiwan, 3Dpt of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, 4Institute of Medical Device and Imaging, National Taiwan University, Taipei, Taiwan

This study investigated whether free-breathing T1-acquisition with the proposed region-based (RB) method is feasible to quantify ECV as an index of diffuse myocardial fibrosis. Thirty-eight patients with non-ischemic cardiomyopathy (NICM) and 20 healthy controls were examined using both breath-hold and free-breathing myocardial T1-acquisitions. ECV was measured from free-breathing images by the RB method, which was compared with the measurement on the standard pixel-wise T1-mapping. Intraclass correlation coefficient of the two methods was 0.915. Patients with NICM showed significantly higher ECV than controls for both methods. Our results suggest that free-breathing T1-acquisition with the RB method is feasible to quantify diffuse myocardial fibrosis, and is comparable to the measurement using the standard T1-mapping.

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