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Abstract #4879

Validation of Diffusion Tensor Imaging in Diseased Myocardium

Irvin Teh1,2, Darryl McClymont2, Marie-Christine Zdora3,4, Hannah J. Whittington2, Katja Gehmlich2, Christoph Rau3,5,6, Craig A. Lygate2, and J├╝rgen E. Schneider1,2

1Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, 2Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 3Diamond Light Source, Didcot, United Kingdom, 4Department of Physics and Astronomy, University College London, London, United Kingdom, 5University of Manchester, Manchester, United Kingdom, 6Feinberg School of Medicine, Northwestern University, Chicago, IL, United States

Diffusion tensor imaging (DTI) has been used in clinical research to identify microstructural changes in the heart following disease. However, the evidence supporting its use in the presence of abnormalities such as scar, hypertrophy and collagen infiltration is limited. Here, we investigate the application of DTI in fixed healthy, infarcted, hypertrophic and fibrotic mouse hearts, and validate these on a voxel-wise basis with high-resolution structure tensor synchrotron radiation imaging. Our findings show good agreement in helix angle estimation between the two imaging modalities across all hearts, and supports the clinical role of DTI in the presence of cardiac pathologies.

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