Abstract #5108

Toward CEST MRI of renal masses: protocol optimization and first preliminary data

Shu Zhang¹, Bian Li¹, Joshua Greer^1,2, Ananth J Madhuranthakam^1,3, Jochen Keupp⁴, Ivan E Dimitrov^3,5, Robert E Lenkinski^1,3, Ivan Pedrosa^1,3, and Elena Vinogradov^1,3

¹Radiology Department, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Biomedical Engineering, University of Texas Dallas, Dallas, TX, United States, ³Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁴Philips Research, Hamburg, Germany, ⁵Philips Healthcare, Gainesville, FL, United States

Chemical Exchange Saturation Transfer (CEST) MRI is emerging as a tool for the studies of human malignancy. However, the translation of CEST into a successful tool for renal cancer characterization has been slow and hampered by technical difficulties associated with body imaging, such as motion, contaminating lipid signals and increased B0 ingomogeneity. Here we optimize CEST protocol for characterization of renal masses and demonstrate CEST measurements are feasible in kidneys using combination of motion synchronization, post-processing registration and lipid artifact removal. In addition, first Renal Cell Carcinoma patient CEST-mDixon data is shown and imaging results are correlated with the pathology.

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