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Abstract #5117

Nuclear Overhauser enhancement effect of low $$$B_{1}$$$ power CEST RF in human brain at 3.0 T

Yuki Kanazawa1, Masafumi Harada1, Mitsuharu Miyoshi2, Ikuho Kosaka3, Kotaro Baba3, Hiroaki Hayashi1, and Yuki Matsumoto4

1Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan, 2Global MR Applications and Workflow, GE Healthcare Japan, Hino, Japan, 3School of Health Sciences, Tokushima University, Tokushima, Japan, 4Graduate school of Health Science, Tokushima University, Tokushima, Japan

The purpose of this study is to clarify the relationship between APT and NOE effects derived from CPE fitting of the human brain on a 3 T MR scanner. CEST imaging with different B1 values of the brain was performed in healthy subjects. The mean NOE values of white matter at 0.5 ┬ÁT were higher than all regions (P < 0.05). CPE-spectrum shows greater sensitivity for both APT and NOE peaks than conventional Z-spectrum and MTRasym. It is found that NOE imaging on a 3.0 T scanner is sensitive on low-B1 power regardless of the CEST fitting process.

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