Abstract #5162

Estimating vertebral bone marrow triglyceride unsaturation based on the extraction of the olefinic peak in short-TE STEAM MRS using a constrained fitting model

Jan Syväri¹, Stefan Ruschke¹, Michael Dieckmeyer¹, Daniela Franz¹, Hans Hauner², Jan S Kirschke³, Thomas Baum³, and Dimitrios Karampinos¹

¹Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany, ²Department of Nutritional Medicine, Technical University of Munich, Freising, Germany, ³Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, Munich, Germany

The measurement of vertebral bone marrow triglyceride unsaturation using single-voxel STEAM MRS serves as a potential biomarker for bone health. The required quantifiction of the olefinic fat peak (OFP) is often prevented by an overlapping water signal. The aim of this study was to investigate the feasibility of measuring the OFP by defining a quantification reliability measure (QRM) based on the comparison of two constrained triglyceride models. Result: The feasibility of estimating the OFP depends on the water linewidth and proton density fat fraction, increases with the QRM and may not be achievable if the water peak and OFP are not intercepting.

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