Abstract #5163

Sex dependence of age-related vertebral bone marrow PDFF and T2 relaxation time changes in a cohort of nearly 200 subjects using multi-TE single-voxel MR spectroscopy

Jan Syväri¹, Stefan Ruschke¹, Michael Dieckmeyer¹, Daniela Franz¹, Hans Hauner², Jan S Kirschke³, Thomas Baum³, and Dimitrios Karampinos¹

¹Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany, ²Department of Nutritional Medicine, Technical University of Munich, Freising, Germany, ³Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, Munich, Germany

Fat quantification of vertebral bone marrow (VBM) has been often performed with single-TE MRS. Using MRS the differences in the T₂-decay of water and fat is neglected and therefore the extracted fat fraction (FF) measure comprises T₂-weighting. The aim of this study was to examine differences between T₂-weighted FF and proton density fat fraction (PDFF) using multi-TE single-voxel MRS and to relate the observed differences with changes in T₂-relaxation of water with age in 197 subjects. The T₂-relaxation of water remained constant in males and showed an age dependence in females resulting in amplified gender differences of T₂-weighted FF with age compared to PDFF.

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