We analysis alterations of volume and shape of subcortical nuclei in a relatively large sample of adult patients with Major Depressive Disorder (MDD) using an automatically segmentation and vertex-based shape analysis protocol. We found that hippocampus, putamen and accumbens were impaired in patients with MDD and subregional shape of hippocampus, accumbens and pallidum may have potential predictive value of treatment response in patients with MDD. Shape analysis may provide more evidence of neuropathology related to depression from a different perspective. Future study should consider shape and volume analysis simultaneously.
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