Diffusion-weighted imaging is a valuable asset in the diagnosis of a plethora of diseases. General guidelines are available when measuring (mono-exponential) diffusion in several organs of interest, but there is less consensus on optimal acquisition parameters for more complex models (e.g., intravoxel incoherent motion, kurtosis). We provide a general, easy to implement, solution scheme (similar to the Cramér–Rao lower bound approach) that can be used to optimize the acquisition protocol with respect to the $$$b$$$-values. We present mathematical proof, and phantom as well as in-vivo measurements that corroborate the viability of our method.
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