Abstract #5564

The Effect of HIV and Aging on Functional Connectivity, Connectome Similarity, and Structural changes

Yuchuan Zhuang¹, Lu Wang², Madalina Tivarus ³, Xing Qiu², Jianhui Zhong³, and Giovanni Schifitto⁴

¹Electrical and Computer Engineering, University of Rochester, Rochester, NY, United States, ²Dept of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, United States, ³Department of Imaging Sciences, University of Rochester, Rochester, NY, United States, ⁴Department of Neurology, University of Rochester, Rochester, NY, United States

We investigated the effect of HIV-infection and aging using resting-state fMRI and T1-weighted structural images. First, we assessed the inter-network functional connectivity and identified 8 resting-state networks associate with normal aging. Second, we constructed a functional connectome similarity as a global measure of neural connectivity pattern to assess the effect of age and HIV infection. Lastly, we measured cortical thickness and brain volumetrics. We found a significant effect of aging but not a definite additive or synergistic effect of HIV infection in all three analyses.

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