Abstract #0127

Multi-vendor multi-site T1ρ and T2 quantification of knee cartilage

Jeehun Kim¹, Kenji Mamoto¹, Richard Lartey¹, Kaipin Xu¹, Matthew Tanaka², Emma Bahroos², Carl S. Winalski¹, Thomas M. Link², Peter A. Hardy³, Qi Peng⁴, Angie Botto-van Bemden⁵, Kecheng Liu⁶, Robert D. Peters⁷, Can Wu⁸, and Xiaojuan Li¹

¹Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, United States, ²University of California, San Francisco (UCSF), San Francisco, CA, United States, ³University of Kentucky, Lexington, KY, United States, ⁴Albert Einstein College of Medicine, Bronx, NY, United States, ⁵Arthritis Foundation, Atlanta, GA, United States, ⁶Siemens Medical Solution Inc, Malvern, PA, United States, ⁷GE Healthcare, Milwaukee, WI, United States, ⁸Philips Healthcare, Andover, MA, United States

T_1ρ and T₂ relaxation times are promising biomarkers for early detection of osteoarthritis due to its sensitivity to cartilage degeneration. Good reliability is essential for these quantitative measures to be widely applicable in clinical trials. We implemented MAPSS T_1ρ and T₂ imaging on multiple platforms (Siemens, GE, Philips) and evaluated the intra-site repeatability and inter-site reproducibility of T_1ρ and T₂ data in a multi-site multi-vendor setting.

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