Abstract #0291

Cerebral hypometabolism measured with intravascular T2-prepared tissue relaxation with inversion recovery (T2-TRIR) and pCASL in adults with sickle cell disease

Lena Vaclavu^1,2, Esben Thade Petersen³, Henri JMM Mutsaerts¹, Jan Petr⁴, Charles BLM Majoie¹, John C Wood⁵, Ed T VanBavel⁶, Bart J Biemond⁷, and Aart J Nederveen¹

¹Department of Radiology & Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, ²C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, ⁴Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany, ⁵Department of Cardiology and Radiology, Children’s Hospital of Los Angeles, Los Angeles, CA, United States, ⁶Department of Biomedical Engineering & Physics, Amsterdam UMC, Amsterdam, Netherlands, ⁷Department of Hematology, Amsterdam UMC, Amsterdam, Netherlands

Cerebral metabolic rate of oxygen (CMRO₂) quantifies the amount of oxygen consumed by the brain, and relies on continuous delivery of nutrients and oxygen via cerebral blood flow (CBF). In sickle cell disease (SCD), CBF is elevated to compensate for chronic anaemia. This study investigates CMRO₂ in adults with SCD using T₂-prepared tissue relaxation with inversion recovery (T₂-TRIR). CBF increased after acetazolamide-induced vasodilation in both groups but CMRO₂ reduced even further in SCD patients while it remained stable in controls. Our results suggest that cerebral shunting is exacerbated by high flow conditions.

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