Abstract #0292

Mean Transit Time and Capillary Transit Time Heterogeneity at the Basal Ganglia of Patients with Huntington’s Disease

Yi-Fen Yen^1,2, Kenneth Kwong^1,2, Suk-Tak Chan^1,2, Steven M. Stufflebeam^1,2, and H. Diana Rosas^1,3

¹Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ²Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ³Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

We identified abnormally long mean transit time (MTT) and large capillary transit time heterogeneity (CTH) in the basal ganglia of ten individuals with Huntington’s disease (HD) as compared to ten healthy control subjects. Since iron is elevated in the putamen and globus pallidus in HD [1], which can lead to an underestimation of relative cerebral blood flow (CBF) and cerebral blood volume (CBV), excessively prolonged MTT and CTH, which are ratios of CBV and CBF, could be utilized as relatively intact parameters for the estimation of perfusion deficits or breakdown in blood-brain barrier.

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