Atlas-based MRI investigations on older adults often utilize young adult standardized templates, such as those of the ICBM. Additionally, a thorough, quantitative assessment of how available standardized, study-specific and age-specific structural templates perform in studies on older adults has not yet been conducted. Here, a new standardized T1-weighted template was developed specifically for studies on older adults, and was compared to 25 other standardized, study-specific, and age-specific templates, in terms of image quality and inter-subject spatial normalization accuracy.
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