Meeting Banner
Abstract #0337

Characterization of perivascular space morphology in healthy volunteers between 21 and 55 years old

Xiaopeng Zong1, Chunfeng Lian1, Jordan Jimenez2, Koji Yamashita1, Dinggang Shen1, and Weili Lin1

1Department of Radiology and BRIC, Univeristy of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2BRIC, Univeristy of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Perivascular spaces (PVS) are an integral part of the brain’s glymphatic system. Although enlarged PVSs are often observed in older population and patient with neurological diseases, normal PVS morphological features in healthy subjects and their age dependences remain poorly understood. We studied the age-dependence of PVS morphology in healthy volunteers aged 21 – 55. The number and diameters of PVSs were positively correlated with age but exhibited large inter-subject variations. We also found clear spatial heterogeneity in the density of visible PVSs. Further studies are needed to realize the utility of PVS as a potential biomarker for aging and neurological diseases.

This abstract and the presentation materials are available to members only; a login is required.

Join Here