Abstract #0426

The influence of temperature on two ex vivo myelin specific imaging protocols: Inhomogeneous Magnetization Transfer and Myelin Water Imaging

Valentin H. Prevost¹, Sarah Morris^2,3, Andrew Yung¹, Irene Vavasour^1,4, Carl Michal³, Erin MacMillan^1,5, Wayne G.R. Moore^2,6, Cornelia Laule^2,3,4,6, Alex MacKay^1,3,4, and Piotr Kozlowski^1,2,3,4,6

¹UBC MRI Research Centre, Vancouver, BC, Canada, ²International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, ³Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, ⁴Department of Radiology, University of British Columbia, Vancouver, BC, Canada, ⁵MR Clinical Science, Philips Healthcare Canada, Markam, ON, Canada, ⁶Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

The impact of temperature on inhomogeneous magnetization transfer (ihMT) measurements in formalin-fixed human brain was studied. White matter (WM) ihMT signal increased with temperature when a T_1D-filter was applied, supporting the hypothesis that components with long T_1D (>1ms) are more sensitive to temperature variations. Grey matter ihMT did not vary with temperature. This suggests a difference in T_1D values between WM and GM, and confirms that several T_1D components contribute to myelin ihMT. Myelin water fraction values decreased with increasing temperature, possibly due to faster exchange between water compartments. Temperature is an important factor to consider in order to characterize the microstructure.

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