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Abstract #0427

Steady-state imaging with “inhomogeneous” MT contrast

Shaihan J Malik1,2, Rui Pedro A.G. Teixeira1,2, and Joseph V Hajnal1,2

1Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

A matrix-based framework for modelling of inhomogeneous MT effects was developed for steady-state gradient echo sequences. This was applied to sequences using multi-band pulses that are designed to create some off-resonance saturation simultaneously with excitation of free water. Simulations and phantom results show that ihMT contrast can be achieved in this way, and in-vivo results show the expected strong white-matter contrast.

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